The Daily Pennsylvanian is a student-run nonprofit.
Please support us by disabling your ad blocker on our site.
Penn Medicine has found a new type of cancer immunotherapy which significantly shrinks tumor growth.
In a recently published study, a research team at Penn's Perelman School of Medicine, which included researchers from other institutions, discovered they could block the production of immune suppressor cells and reduce tumors by inhibiting a certain molecule in human cells and in a mouse model, Penn Medicine News reported.
Checkpoint inhibitors block a specific type of protein and help keep immune responses from being too strong while also, inadvertently, killing cancer cells. These types of immunotherapies have changed the ways in which cancer is treated, by showing survival benefits where traditional therapies, like chemotherapy, do not work for some patients.
Penn Medicine researchers have been studying c-Rel, a specific type of molecule in cells, for two decades and were surprised to discover it plays a role in tumor growth as it was considered more to be a promoter of immune responses.
While researching c-Rel in inflammation and autoimmune diseases, the team discovered a relationship between c-Rel and myeloid-derived suppressor cells (MDSC), which were known to prevent the immune system from attacking cancer cells. This led to the finding of a previously unknown pathway for how cancer invades the body with the MDSC.
The researchers found tumor cells would change the function of c-Rel to produce MDSC, which prevents the immune system from attacking cancer cells.
With success in the preclinical setting, Penn Medicine News reported that the next step for this new immunotherapy is to assess the safety of the drug before moving forward with clinical trials.
More Like This
"type" - Google News
June 09, 2020 at 01:00PM
https://ift.tt/2Ak4duH
Penn Medicine study discovers new type of cancer immunotherapy - The Daily Pennsylvanian
"type" - Google News
https://ift.tt/2WhN8Zg
https://ift.tt/2YrjQdq
Bagikan Berita Ini
0 Response to "Penn Medicine study discovers new type of cancer immunotherapy - The Daily Pennsylvanian"
Post a Comment