“Our findings of a sex and BMI interaction with regard to AFib risk suggest that the arrhythmogenic effects of adiposity in diabetes may differ by sex, such that men with higher BMI have a substantially increased risk of AFib, whereas women with higher BMI may not,” wrote lead author Matthew J. Singleton, MD, a cardiologist at Wake Forest School of Medicine in Winston-Salem, North Carolina, and colleagues. “One possible explanation for these findings is that, for any given degree of obesity, men have a much higher risk of obstructive sleep apnea that women. Obstructive sleep apnea has potent arrhythmogenic effects and is strongly associated with incident AFib, so a differential sensitivity to obstructive sleep apnea between men and women may explain why obesity is more strongly associated with incident AFib in men.”
These findings are especially important, the authors added, because they suggest “guidance about maintenance of ideal body weight and the effects of obesity could be personalized based on a patient’s sex.”
“With emerging data suggesting that some hypoglycemic agents may lower the risk of AFib, matching the right patient with the right therapy to both control diabetes and lower the risk of downstream complications such as AFib will be increasingly important,” they wrote. “In addition, inclusion of interaction terms for sex and BMI in models may improve risk prediction.”
There were certain limitations to the this research. Data was incomplete on the race of study participants, for instance, and it is possible these findings don’t apply to patients with type 2 diabetes and a low risk of cardiovascular disease.
The full analysis is available here.
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November 05, 2020 at 12:32AM
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Obese men with type 2 diabetes face an increased risk of AFib - Cardiovascular Business
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