Dr. Breton reports receiving consulting fees from Air Liquide, grant support, paid to the University of Virginia, consulting fees, and conference attendance fees from Dexcom, grant support, paid to the University of Virginia, and conference attendance fees from Tandem Diabetes Care, and holding pending patent 61/500.545 PCT/US2012/043910 on DiAs (a scalable system for monitoring and control of blood glucose fluctuation; licensed to Dexcom), patent 10420489 on a system coordinator and modular architecture for open-loop control of diabetes (licensed to Dexcom), pending patent 62/173.080 PCT/US2016/036729 on continuous glucose monitoring (CGM)–based fault detection and mitigation of insulin delivery and monitoring systems via metabolic state (licensed to Dexcom), and patent 9750438 on CGM-based prevention of hypoglycemia through hypoglycemia rise assessment and smooth reduction of insulin (licensed to Dexcom); Dr. Kanapka, receiving grant support, paid to the Jaeb Center for Health Research, from Tandem Diabetes Care; Dr. Beck, receiving grant support and donated supplies, paid to the Jaeb Center for Health Research, from Abbott Diabetes Care, Ascensia Diabetes Care US, Beta Bionics, and Roche Diabetes Care, grant support, donated supplies, and consulting fees, paid to the Jaeb Center for Health Research, from Dexcom, Novo Nordisk, and Tandem Diabetes Care, grant support and consulting fees, paid to the Jaeb Center for Health Research, from Bigfoot Biomedical, and consulting fees, paid to the Jaeb Center for Health Research, from Eli Lilly and Insulet; Dr. Forlenza, receiving grant support, paid to the Barbara Davis Center, and consulting fees from Abbott Diabetes Care, Dexcom, Insulet, Medtronic MiniMed, and Tandem Diabetes Care, and consulting fees from Eli Lilly; Dr. Schoelwer, receiving grant support, paid to the University of Virginia, from Medtronic and Tandem Diabetes Care; Dr. Ruedy, receiving grant support and donated supplies, paid to the Jaeb Center for Health Research, from Abbott Diabetes Care, Beta Bionics, and Dexcom, and grant support, paid to the Jaeb Center for Health Research, from Tandem Diabetes Care; Dr. Hsu, owning stock in Dexcom and Tandem Diabetes Care; Dr. Kollman, receiving grant support, paid to the Jaeb Center for Health Research, from Tandem Diabetes Care; Dr. Dokken, being employed by and owning stock in Tandem Diabetes Care; Dr. Weinzimer, receiving consulting fees from Eli Lilly, Insulet, Sanofi US Services, and Zealand, grant support, paid to Yale University, from Medtronic, and consulting fees and lecture fees from Tandem Diabetes Care; Dr. DeBoer, receiving grant support, paid to his institution, from Medtronic USA and Tandem Diabetes Care; Dr. Buckingham, receiving grant support, paid to Stanford University, donated supplies, and advisory board fees from Covatec, grant support from Dexcom, grant support and honoraria from Insulet, grant support, paid to Stanford University, and advisory board fees from Medtronic MiniMed, and grant support, paid to Stanford University, from Tandem Diabetes care; Dr. Cherñavvsky, being employed by Dexcom; and Dr. Wadwa, receiving grant support, paid to the University of Colorado, from Bigfoot Biomedical, MannKind, and Novo Nordisk, grant support, paid to the University of Colorado, and lecture fees from Dexcom, grant support, paid to the University of Colorado, and advisory board fees from Eli Lilly and Medtronic, and grant support, paid to the University of Colorado, travel support, and lecture fees from Tandem Diabetes Care. No other potential conflict of interest relevant to this article was reported.
Drs. Breton, Beck, and Wadwa contributed equally to this article.
A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.
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A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes - nejm.org
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